Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and a receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals 41-22.

Brock Purdy’s return went perfectly on Sunday afternoon. The San Francisco 49ers quarterback started after missing six straight games due to a toe injury, and he had no issue leading the 49ers to a commanding 41-22 win over the Arizona Cardinals. Purdy went 19-of-26 passing for 200 yards with 3 touchdowns.

The 49ers have six players on their report with injuries, and five have no game status designation while fully practicing Friday. Only starting cornerback Deommodore Lenoir is questionable. He was added to the report as limited Thursday with a calf injury suffered in practice and did not practice Friday.

San Francisco 49ers QB Brock Purdy had a strong take on the team's Super Bowl chances after he made his return in Week 11.

Ahead of their game against the Cardinals, the 49ers got a bunch of great health news, though they did add one player to the injury report.

Cornerback Deommodore Lenoir (calf) is the only 49ers player with an injury designation. He is questionable after being downgraded to out of practice on Friday. Defensive tackle Alfred Collins (hip) and linebacker Dee Winters (knee/knee) returned to full participation in Friday's practice.

Though he'll miss Week 11, San Francisco 49ers wideout Brandon Aiyuk is expected to return in the next few weeks.

The San Francisco 49ers gain a health edge with key players back. At the time, the Cardinals faced numerous injuries. Important information before kickoff.