Chemotherapeutic alkylating agents induce a range of cytotoxic and mutagenic adducts onto DNA. Alkylating agent-induced damage to DNA is sensed and repaired by different cellular mechanisms, including ...

Chemists at the Max-Planck-Institut für Kohlenforschung have developed a practical two-step method for alkylating alkenes via thianthrenation, addressing a long-standing synthetic challenge. This ...

SINCE the introduction of nitrogen mustard, methyl-bis-β-(chloroethyl)-amine, or HN 2 (Fig. 1), as a therapeutic agent in human cancer a number of analogues and related alkylating agents have been ...

A phase I/II, open-label, dose-escalation, and cohort-expansion study evaluating the safety, pharmacokinetics, and therapeutic activity of OBI-999 in patients with advanced solid tumors. This is an ...

None of the above studies reported increased risk of breast cancer after leukemia, or evaluated the influence of chemotherapy on breast cancer risk in survivors unexposed to chest radiotherapy.