Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the ...

Apical localisation of CFTR protein and its chloride channel activity strictly depend on interactions of its PDZ (for postsynaptic density 95/disclarge/zona occludens)-interacting domain in the C ...

New research findings add further clarity to a question that has polarized the cystic fibrosis (CF) research community. It is well established that people with cystic fibrosis have two faulty copies ...

Researchers studying the root cause of cystic fibrosis have made a major advance in our understanding of silent gene changes with implications for the complexity of cystic fibrosis. The findings are ...

Mutation of one gene is all it takes to get cystic fibrosis, but disease severity depends on many other genes and proteins. For the first time, researchers identified genetic pathways that play major ...

Edited By: Karen Young Kreeger C.L. Ward, S. Omura, R.R. Kopito, "Degradation of CFTR by the ubiquitin-proteasome pathway," Cell, 83:121-7, 1995. (Cited in nearly 50 publications as of March 1997) ...

January 12, 2016 CHAPEL HILL, NC - It is well established that people with cystic fibrosis (CF) have two faulty copies of the CFTR gene, but debate continues on the question of whether certain ...

February 24, 2015 CHAPEL HILL, NC - Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at ...

Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at the UNC School of Medicine have ...