In the earliest stages of life, mammalian embryos start as a disorganized cluster of cells. As development progresses, these cells become organized into well-defined shapes and structures. This ...

Gene expression reveals that different types of human cell can work as a unit. These cellular modules, found in several tissues, change during disease. However, suitable computational methods are ...

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial ...

Scientists at Duke-NUS Medical School have developed two powerful computational tools that could transform how researchers study the "conversations" between cells inside the body. The tools, called ...

Epithelial tissues are in constant interaction with their environment. Maintaining their functionality requires dynamic balance (homeostasis) and that their cell numbers are tightly regulated. This is ...

Dissociating tissues into single cells is a core laboratory technique and vital for widely used applications such as next-generation sequencing or flow cytometry. Scientists who employ tissue ...

How can we ensure that life-saving drugs or genetic therapies reach their intended target cells without causing harmful side effects? Researchers have taken an important step to answer this question.

These images use color markers—blue for nuclei, red for cell membranes, and green for fluid—to show that spaces between cells shrink as fluid moves out during tissue compression, from left to right ...

Immune responses rely on the efficient movement of immune cells within the complex and geometrically unpredictable three-dimensional tissues that make up our bodies. Recent research by the Sixt group ...

Regrowing a lost finger, hand or even an entire limb has long been considered impossible for humans.While salamanders and ...

Five animal species can rebuild organs, limbs, and tissues that most vertebrates permanently lose after injury. Planarians regrow entire bodies from tiny fragments using adult pluripotent stem cells ...

Patients with lupus nephritis receiving obinutuzumab plus standard therapy demonstrated high rates of complete histologic remission.