Point mutations represent the majority of known pathogenic human genetic variants 1. Base editors enable the direct installation and correction of targeted point mutations in genomic DNA. These fusion ...
In summary, MBD4 deficiency increased the sensitivity of cancer cell lines to cytidine analogs (gemcitabine and cytarabine), but not to other classes of chemotherapeutic agents, including dacarbazine, ...
Genotyping of CDA was performed by a direct sequencing of DNA obtained from the peripheral blood of Japanese gemcitabine-naïve cancer patients (n = 256). The patients recruited to the association ...
Phase II Study of Carboplatin, Paclitaxel, and Bevacizumab With Maintenance Bevacizumab As First-Line Chemotherapy for Advanced Müllerian Tumors A simple test to evaluate CDA phenotypic status was ...
Cytidine 5′-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is analogous to the better-known ATP, but with cytidine as the base instead of adenine. It is a substrate in the ...
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