The entry of HIV-1 into host cells is mediated by precise interactions between viral envelope glycoproteins and cellular receptors. Fusion inhibitors, which disrupt these interactions—particularly by ...

Enfuvirtide used as a single agent was originally studied in 17 HIV-infected patients. [8] Seven of these individuals had not previously been exposed to antiretrovirals, and 10 had been previously ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Biomea Fusion Inc. has prepared new fused pyrimidine compounds acting as menin (MEN1)/KMT2A (MLL) interaction inhibitors. They are reported to be potentially useful for the treatment of cancer, ...

Announcing a new article publication for Zoonoses journal. Lassa virus (LASV) glycoprotein complex (GPC) contains retained stable-signal peptide (SSP), glycoprotein 1 (GP1), and glycoprotein 2 (GP2).