No man is an island, and no neuron is either: complex, intricate connections between and among brain cells are needed for the brain to do its job correctly. Now, researchers from Japan have uncovered ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Longitudinal variability in symptom burden for patients with prostate cancer (PC). This is an ASCO Meeting Abstract from the 2023 ASCO Annual Meeting I. This abstract does not include a full text ...

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Alphaherpesviruses hijack host epigenetic regulation by promoting HDAC1/2 nuclear export and degradation to activate the DNA damage response, revealing new antiviral therapeutic targets.

In a recent study published in the journal Science Advances, a group of researchers investigated the role of histone modifications in human aging by developing and evaluating histone-specific age ...

Researchers at Baylor College of Medicine and collaborating institutions are challenging the traditional understanding of how cancer drugs called histone deacetylase (HDAC) inhibitors function. For ...

Before a newly synthesized protein can undergo folding, it must be processed and transported to the correct location within the cell after emerging from the ribosome. N-terminal acetylation ...

In human ES cell-derived cortical neurons (upper left), single-molecule CREB dynamics was observed (upper right). Activity-dependent repetitive CREB binding to DNA occurred at histone acetylation ...

What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the N-terminal tails of histone proteins. Some posit that ...