With the matchup a couple days away, we have our first inclination as to who could play, and will not. On Thursday, the ACC released the first availability report for Louisville's matchup vs. SMU. An updated report will come out at 8:00 p.m. EST on Friday, and a final report will then be released two hours before kickoff.

Louisville running back Keyjuan Brown, who has filled in exceptionally for injured preseason All-American Isaac Brown, is now sidelined by injury himself, while quarterback Miller Moss

Who will miss the Louisville Cardinals' Week 13 ACC college football game vs SMU? Here's the latest injury report.

When Louisville landed five-star guard Mikel Brown Jr., it was the latest indication that the program was heading in the right direction after a disastrous stretch under former coach Kenny Payne. Brown, the No. 6 overall prospect in the 2025 recruiting cycle by 247Sports, marked the school's highest-ranked commitment in the modern era.

Our college football Week 13 picks for UofL vs SMU, UK vs Vanderbilt, LSU vs WKU, BYU vs Cincinnati and Tennessee vs Florida.