A recent study published in Science Advances showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike N-glycosylation patterns, intracellular lectins, as well as the associated ...
In a recent review published in Cellular and Molecular Immunology, researchers discuss the regulatory roles of glycans and glycan-binding proteins (GBPs) in modulating immune responses, particularly ...
A type of glycan called “N-glycan” is usually extended by the actions of several enzymes (glycosyltransferases). The terminal sugar “sialic acid” increases protein stability in blood. Once B4GALNT3 ...
N-glycosylation is one of the most common posttranslational modifications encountered on biopharmaceuticals. While the modification is often critical to achieve efficient folding and secretion of the ...
Glycosylation is not just a quality attribute; it is a critical determinant of efficacy and immunogenicity for every biologic on the market. For monoclonal antibodies (mAbs), antibody-drug conjugates ...
Specific glycans attached to the GnT-IVa and GnT-IVb can bind to the enzyme’s ligand-binding site, interfering with recognition and binding to the glycosylation proteins’ normal glycoprotein ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results