Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

C-to-T transitions in CpG dinucleotides are the most prevalent mutations in human cancers and genetic diseases. These mutations have been attributed to deamination of 5-methylcytosine (5mC), an ...

The correction of errors during mitochondrial DNA replication by the proofreading function of DNA polymerase-γ is crucial for maintaining the integrity of the mitochondrial genome and the production ...

The radiation in space is not great for biological health. Space radiation is known to damage DNA. Many types of human cells have to frequently divide to replace cells that are worn out, old, or ...

On 22 May 2019, scientists from Queen's University boarded a modified Falcon 20 aircraft at Ottawa airport. Scheduled was a ‘vomit comet’ flight, where the plane repeatedly climbs to 8km in a steep ...

I have two domains. Let's call them domain.com and sub.domain.com. There are two DC's in each domain. I'm trying to configure dc2.domain.com to be a Global Catalog. When I do this, I get the following ...