Gene transcription produces pre-messenger RNAs (pre-mRNA) that are composed of exons and introns as the first RNA species. Subsequent splicing consists of the deletion of introns and the specific ...
A crystal structure of a portion of RNA provides researchers with new insight about a key process along the way to protein synthesis. Before protein synthesis can proceed, noncoding regions (introns) ...
Alison Tang (UC Santa Cruz) describes her lab’s studies on full-length transcript characterization of the mutated SF3B1 transcriptome in chronic lymphocytic leukemia Sponsored content brought to you ...
Proper expression of proteins in eukaryotic cells requires precise stitching of protein-coding fragments, or exons, from precursor mRNAs that also contain non-coding introns. This process, known as ...
Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...
The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...
Alternative splicing (AS) is a key technique for increasing transcriptome and proteomic diversity from a small genome. Almost all human gene transcripts are alternatively spliced, resulting in protein ...
Individuals with mutations in the ATM gene develop ataxia-telangiectasia, a neurodegenrative disorder characterized by immunological defects and cancer predisposition. In an Advanced Online ...
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