Type II topoisomerases cleave one DNA duplex (the G, or gate, segment) using two tyrosine residues to attack opposite strands of the phosphodiester backbone. In the process, the enzyme becomes ...
Cell proliferation is controlled by various cell cycle regulators. Changes in pathways regulating the cell cycle are linked to tumorigenesis. Studies have demonstrated that in rapidly proliferating ...
A UC Berkeley group has worked out the mechanics of how the enzyme Type II topoisomerase binds a broken DNA strand and stitches it back together before releasing it. Colored portions highlight ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results