Sublocade (buprenorphine) is a brand-name subcutaneous injection prescribed for opioid use disorder. It works to help reduce the need for opioids by acting in certain areas of the brain called mu and ...

PN6047 is a first-in-class small molecule that selectively activates the delta opioid receptor (DOR), avoiding interaction with the mu opioid receptor that is the basis of the addiction and other ...

Distinct brain circuits drive two key components of addiction to the synthetic opioid drug fentanyl, according to a new finding published in Nature (2024, DOI: 10.1038/s41586-024-07440-x). The ...

Ketamine use disorder is a serious and growing problem of increased non-prescribed ketamine use among young users, ages 16-30. Linda Cottler, Ph.D., and her fellow researchers at the University of ...

University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...