“Last week, President Joe Biden was seen for a new finding of a prostate nodule after experiencing increasing urinary symptoms,” his personal office said in a statement. “On Friday he was diagnosed with prostate cancer, characterized by a Gleason score of 9 (Grade Group 5) with metastasis to the bone.”

It’s aggressive. The cells have an ugly, disordered appearance under a microscope. Pathologists gave them a Gleason score of 9 (out of 10) for their likelihood to advance quickly. The cancer has already moved from Biden’s prostate to his bones, which means it cannot be cured — only controlled with drugs.