The circulating bird flu has become “widespread” in Massachusetts, as officials believe the virus has killed 500 to 1,000 wild birds across the region.

Bird flu cases are still rising in the U.S. as the virus continues to devastate poultry farms. More than 145 million chickens, ducks, turkeys and other fowl have been slaughtered across the United States since the outbreak began in January 2022. As for humans, 67 people have been infected, according to the Centers for Disease Control.

Massachusetts officials announced Wednesday that bird flu is now considered to be “widespread” in the state and urged the public to avoid handling birds or other animals that are dead or appear sick.