Inter Miami host Pumas UNAM for their third match of the 2025 Leagues Cup Phase One, but all the attention is on Lionel Messi, who was subbed off in the previous game. Here’s what you need to know about his status.

Lionel Messi was on a generational run with Inter Miami, dominating both MLS and the League’s Cup. But in the second match against Necaxa, everything changed as Messi picked up an injury and left the field just 11 minutes into the game.

Lionel Messi is officially ruled out of Inter Miami's key Leagues Cup clash against Pumas UNAM due to a minor muscle injury. Coach Javier Mascherano confirmed Messi won’t feature in Wednesday's game but expressed optimism about his recovery.