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Cancer Research6d
NextCure Buys ADC for Up to $745 Million
Maryland–based biotech NextCure acquired the rights to the CDH6-targeting antibody–drug conjugate (ADC) SIM0505 from Chinese company Simcere Zaiming for up to $745 million in combined upfront and ...
Cancer Research9d
American Association for Cancer Research
This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...
Cancer Research9d
Abstract P1-06-12: Efficacy and safety of the addition of prophylactic atropine to patients with metastatic triple-negative breast cancer treated with sacituzumab govitecan: a ...
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Cancer Research11d
Cholesterol Metabolism Dictates Secondary Organ Colonization in Pancreatic Cancer
Major Finding: PCSK9 regulates cholesterol uptake and controls the trajectory of metastasis to secondary organs in pancreatic ductal adenocarcinoma (PDAC). Concept: Cholesterol uptake supports ...
Cancer Research13d
NIH Staff Call Out Leadership
In a letter addressed to NIH director Jay Bhattacharya, MD, dubbed the Bethesda Declaration, NIH staff members criticized many of the agency’s actions under the Trump administration. Representing all ...
Cancer Research6d
SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T-cell Activity in Hepatocellular Carcinoma
1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University, ...
Cancer Research9d
The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
1Hunan Key Laboratory of Skin Cancer and Psoriasis, Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China ...
Cancer Research9d
Reclassification of ATM Missense Variants of Uncertain Significance by Integrating Results from Systematic Functional Assays into an ACMG Points–Based Framework
1Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen, Essen, Germany. 2Department of Otorhinolaryngology & Head/Neck Surgery, University Hospital ...
Cancer Research4d
Special Series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI
Publishing in July 2025 to coincide with the AACR Special Conference in Cancer Research: Artificial Intelligence and Machine Learning, the series will continue through December 2025! Technological ...
Cancer Research11d
T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-Selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. 2Abramson Cancer Center and Abramson Family Cancer Research Institute, University of ...
Cancer Research10d
METTL3 Inhibition Restores PD-L1 Expression and CD8
1Key Laboratory of Dunhuang Medicine and Transformation at Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou, China. 2Provincial-Level Key Laboratory for Molecular ...