New Analyses from Three Trials in Obstructive HCM Support Findings from Previously Published Data on MYQORZO™ (aficamten) ...

BACKGROUND: Right ventricular failure drives both morbidity and mortality in pulmonary arterial hypertension (PAH), but the mechanism of transition from compensated right ventricle (cRV) to ...

1 Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Peoples' Republic of China 2 Translational Medicine ...

The resistance to chemotherapeutics is one major challenge to clinical effectiveness of cancer treatment and primarily interpreted by various biochemical mechanisms. This study provides compelling ...

Objectives Patients with rheumatoid arthritis (RA) display an increased risk of heart failure independent of traditional cardiovascular risk factors. To elucidate myocardial disease in RA, we have ...

Human embryo at the blastocyst stage ready to implant. The nuclear envelope of the cells appears in blue and the actin cytoskeleton in orange. Credit: Julie Firmin et Jean-Léon Maître A breakthrough ...

Human embryo compaction, an essential step in the first days of an embryo's development, is driven by the contractility of its cells. These results contradict the presupposed driving role of cell ...

Abstract: The evaluation of ventricular contractility is an important factor helping doctors in choosing the appropriate therapy for abnormal heart functioning occurring at the level of ...

Cardiomyocyte-specific ZBTB20 knockout mice were generated by crossing ZBTB20 flox mice with Myh6-Cre mice. Echocardiography, blood pressure measurements, Langendorff perfusion, histological analysis ...

† National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan ‡ Department of Applied Chemistry and Institute of Molecular Science, National Chiao Tung University, 1001 University ...

Lenox Hill Hospital is the first in New York City to implant a cardiac contractility modulator, a first-of-its-kind device designed to treat heart failure. The minimally invasive, FDA-approved device ...