Kansas City comes into this one winners of five of their last six—as well as three straight—after an 0–2 start to the season. Patrick Mahomes enters as the MVP-favorite and leads the league in touchdown passes, while the Chiefs’ defense has allowed 17 or fewer points in each of their past two games.

The Bills have tried to follow the Eagles blueprint to beating Mahomes by beefing up their front four. They signed Joey Bosa in free agency this offseason, extended edge rusher Gregory Rousseau and used their first five draft picks on defense, including three along the defensive line ( T.J. Sanders, Landon Jackson, Deone Walker ).