Proteasome inhibitors (INN stem –zomib) [1] are drugs that block the action of proteasomes. Proteasomes are large proteins complexes that are used to break down other proteins. These …

Compare proteasome inhibitors. View important safety information, ratings, user reviews, popularity and more.

Proteasome inhibitors (PIs) block the proteolytic activity of the proteasome complex, leading to protein accumulation, even aggregation, and the activation of apoptotic pathways and cell …

Jul 27, 2025 · Proteasome inhibitor drugs are targeted therapies used to treat certain diseases, particularly in oncology. These medications operate by interfering with a specific cellular …

Jan 6, 2020 · Proteasome inhibitors are an important class of drugs for the treatment of multiple myeloma and mantle cell lymphoma, and they are being investigated for other diseases. …

Aug 16, 2025 · Proteasome inhibitors are a type of drug that prevents proteasomes, a kind of “garbage disposal” system inside a cell, from gobbling up (or breaking down) excess proteins.

Feb 5, 2020 · As a therapeutic target, proteasome inhibitors have been approved for the treatment of multiple myeloma and mantle cell lymphoma. However, inability to sufficiently inhibit …

Proteasome inhibitors are small-molecule drugs designed to target the proteasome, a crucial protein complex that degrades unwanted or damaged proteins within cells. This process, …

Proteasome inhibitors work by blocking the proteasome's ability to degrade ubiquitinated proteins. This leads to the accumulation of these proteins within the cell, disrupting various signaling …

May 6, 2021 · Proteasomes are large multicatalytic protein complexes that function in the degradation of proteins into peptides. Drugs that inhibit one or more of the proteasome’s …