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Zyrtec (cetirizine) and Claritin (loratadine) are second-generation ... are any interactions between second generation antihistamines and herbal ...These drugs have different active ingredients. The active ingredient in Zyrtec is cetirizine. In Claritin, it's loratadine. ... However, newer antihistamines like Zyrtec and Claritin are less likely ...
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